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Alternative Name
Acute myeloid leukemia
Test Description

Probes: 5q-, -5 (5p15.2, 5q33-34) | 7q-, -7 (7q31, Cen 7) | Trisomy 8 (Cen 8) | MLL (11q23) | RUNX1T1/RUNX1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;16)
Probes may be ordered separately.
Disease(s): AML
Note: STAT processing is available by request for PML-RARA. Note STAT along with MD contact name and phone number to receive STAT results.

Clinical Significance

The AML FISH panel is used for the detection of chromosome aberrations observed in AML, which aid in diagnosis, prognosis and/or therapy selection.

Specimen Requirements
  • Bone Marrow Aspirate: 1-2mL Sodium Heparin Tube. EDTA tube is acceptable

  • Peripheral Blood: 2-5mL Sodium Heparin Tube. EDTA tube is acceptable

  • Fresh, Unfixed Tissue: Tissue in RPMI

  • Fluids: Equal parts RPMI to specimen volume.

  • Paraffin or Cut Slides: N/A

  • Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.

Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*
88374x6, 88367x1 automated. Codes may differ if manual analysis is performed.
Turnaround Time

3-5 days. STAT results for PML-RARA, when requested, are reported 12-24 hours from receipt in the NeoGenomics laboratory

New York Approved
Level of Service

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.