The NeoTYPE GIST/Soft Tissue Tumor Profile analyzes 43 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (38 genes + 2 biomarkers): AKT1, AKT2, AKT3, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, GNAS, HRAS, KIT, KRAS, MAP2K1, MET, Microsatellite Instability (MSI), NF1, NRAS, NTRK1 fusions, NTRK2 fusions, NTRK3 fusions, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, SDHA, SDHB, SDHC, SDHD, SMAD4, SMO, SRC, TERT Promoter, TP53, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, PTEN (tech-only available) IHC (1 biomarker): PD-L1 LDT (tech-only available).
NeoTYPE® GIST and Soft Tissue Tumor Profile
- Next Generation Sequencing (NGS)
Specimen Requirements
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81457x1, 88377x2, 88360x1
Turnaround time
14 Days
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
Level of Service
- Global
Integrations
Request electronic integrations →
New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| SNVs + Indels | |||||
|---|---|---|---|---|---|
| AKT1 | AKT2 | AKT3 | ARID1A | ATM | BRAF |
| CDKN2A | CTNNB1 | ERBB2 | ERBB4 | FGFR1 | FGFR2 |
| FGFR3 | GNAS | HRAS | KIT | KRAS | MAP2K1 |
| MET | NF1 | NRAS | NTRK1 | NTRK2 | NTRK3 |
| PDGFRA | PIK3CA | PTEN | PTPN11 | RB1 | SDHA |
| SDHB | SDHC | SDHD | SMAD4 | SMO | SRC |
| TERT | TP53 | ||||
| Genomic Signatures | |||||
|---|---|---|---|---|---|
| MSI | TMB | ||||
Immunohistochemistry (IHC)
| Expression | |||||
|---|---|---|---|---|---|
| PD-L1 | |||||
Fluorescence In Situ Hybridization (FISH)
| Amplification(s) | |||||
|---|---|---|---|---|---|
| MET | |||||
| Deletion(s) | |||||
|---|---|---|---|---|---|
| PTEN | |||||
Last Updated: March 09, 2026