NeoTYPE® ALL Profile

The NeoTYPE ALL Profile analyzes 38 genes to detect DNA and RNA alterations through a combination of next-generation sequencing (NGS) and FISH as noted below. Test reports include a summary interpretation of all results together. FISH components may be ordered as "Tech-Only" by pathology clients who wish to perform the professional component. Test may be ordered as "Molecular only" by clients who wish to opt out of the FISH components. DNA Sequencing: SNVs/InDels (21 Genes): ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FGFR2, FGFR3, FLT3, IKZF1, IL7R, JAK1, JAK2, JAK3, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, SH2B3, and TP53 Copy Number Variations (3 Genes): CDKN2A, IKZF1, and TP53 Note: Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes. RNA Sequencing: Fusions (30 Genes): ABL1, ABL2, BCR, CRLF2, CSF1R, EPOR, ETV6, FGFR1, FLT3, IKZF1, JAK2, KMT2A, MEF2D, MLLT10, NTRK1, NTRK2, NTRK3, NUP98, PAX5, PBX1, PDGFRA, PDGFRB, PTK2B, RUNX1, TAL1, TCF3, TLX1, TLX3, TYK2, and ZNF384 Gene Overexpression (2 Genes): CRLF2 and EPOR Note: Analysis not available for FFPE samples FISH (2 Genes): CRLF2 (Xp22.33/Yp11.32) | EPOR (19p13.2).