NTRK & RET NGS Fusion Panel

The NTRK & RET NGS Fusion Profile is an RNA-based next-generation sequencing panel that detects translocations and fusions of the genes NTRK1, NTRK2, NTRK3 and RET with known and novel fusion partners. Point mutations in select exons of these four genes are also detected. Examples of some of the published fusions detectable in this test include CD74-NTRK1, LMNA-NTRK1, MPRIP-NTRK1, TPM3-NTRK1, SQSTM1-NTRK1, PPL-NTRK1, AFAP1-NTRK2, PAN3-NTRK2, TRIM24-NTRK2, BTBD1-NTRK3, ETV6-NTRK3, CCD6-RET (aka RET-PTC1), KIF5B-RET, and NCOA4-RET (aka RET-PTC3). This test may be used to select patients for the following FDA-approved therapies: NTRK- ROZLYTREK® (entrectinib), VITRAKVI® (larotrectinib) RET- GAVRETO (pralsetinib), RETEVMO (selpercatinib) See also NTRK NGS Fusion Panel and Lung NGS Fusion Panel (Complete or Limited).