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Early-stage NSCLC Panel
- FISH
- Immunohistochemistry (IHC)
- Molecular
The Early-stage NSCLC Panel analyzes 4 relevant and actionable biomarkers through a combination of multi-modality methods: EGFR (PCR), ALK (FISH), ROS1 (FISH), and PD-L1 22C3 (IHC). EGFR alterations are detected using PCR amplification and detection of target DNA using complementary primer pairs and oligonucleotide probes with fluorescent dyes. The EGFR PCR component of this panel has been designed to detect EGFR highly recurrent somatic mutations in exons 18, 19, 20, and 21 of EGFR in eight reactions (Exon 18 G719X; Exon 19 deletions; Exon 20 T790M, C797S, Exon 20-Ins and S768I; Exon 21 L858R, L861Q). Some less common EGFR mutations are not detectable in this test. For a full list of EGFR variants detectable in this assay, please contact NeoGenomics client services. Test may be ordered with an opt out of PD-L1 22C3 (IHC).
Turnaround time
7 Days
Level of Service
- Global
New York Approved: Yes
Specimen Requirements
Paraffin Block: 1 Block sent with a cold pack. No zinc or mercury fixatives. H&E: 1 unstained slide cut at 4-5 microns required. Cut Slides: 10 unstained slides cut at 4-5 microns. Minimum of ≥10mm2 surface area with ≥20% tumor nuclei. Positively charged slides in 10% NBF. No zinc or mercury fixatives.
Storage and Transportation
Storage & Transportation: Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81235x1, 88377x2, 88360x1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 16, 2025