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AML Standard FISH Panel
- FISH
Probes: CBFB inv(16), t(6;16) | KMT2A (MLL) (11q23) | PML/RARA t(15;17) | RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | RPN1, MECOM (3q21, 3q26.2)
Optional Reflex (available with Global cases only): 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | DEK/NUP214 (CAN) t(6;9) | p53 (17p13.1)/NF1 (17q11) | NUP98 (11p15) when the main panel is negative.
Probes may be ordered separately. Reflex results will be reported separately as AML Standard Reflex Panel.
Disease(s): Acute myeloid leukemia
Note: STAT processing is available by request for PML-RARA. Note STAT along with MD contact name and phone number to receive STAT results.
Turnaround time
3-5 Days. STAT results for PML-RARA, when requested, are reported 12-24 hours from receipt in the NeoGenomics laboratory
Level of Service
- Global
- Technical Only
New York Approved: Yes
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable. Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable. Fresh, Unfixed Tissue: Tissue in RPMI. Bone Marrow/ Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: minimum 7 slides labeled with specimen type. Fluids: Equal parts RPMI to specimen volume. Fixed Cell Suspension: A client fixed cell suspension may be submitted for testing as long as it is received in 3:1 Methanol:Glacial Acetic Acid. Paraffin Block or Cut Slides: Not available. Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation
Storage & Transportation: Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x5 automated. If reflex is added, add 88374x5.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: March 04, 2025