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PSAP/HPAP
- Immunohistochemistry (IHC)
Prostate specific acid phosphatase/human prostatic acid phosphatse (PSAP/HPAP) is a 100kDa glycoprotein present in high concentration in the prostate gland and its secretions. PSAP is specific to the benign or malignant epithelial cells of the prostate gland. Prostatic stroma, urethra and the basal cells stain negatively. Also, epithelial cells injured due to inflammation, infarction, etc. and areas of squamous metaplasia of the prostatic acini show loss of PSAP activity. Nearly all metastases of prostatic carcinoma, irrespective of site, demonstrate PSAP immunoreactivity.
Turnaround time
1 Day
Level of Service
- Technical Only
New York Approved: Yes
Specimen Requirements
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88342 x 1 or 88341 x 1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 22, 2025