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Perforin
- Immunohistochemistry (IHC)
Perforin is a protein found in cytoplasmic granules of cytotoxic T-lymphocytes (CTLs). CTLs bind to cells that express foreign antigens and induce them to lyse. Perforin expression is significantly induced in CD8 positive T-cells, but to lesser extent in gamma/delta T-cells and NK cells. This antibody may be of value in the detection of perforin in CTLs in severe cases of graft versus host disease, chronic renal rejection and peripheral T-cell lymphomas. In addition, perforin antibody may also be useful for the detection of NK cell lymphomas, all of which express the perforin protein.
Turnaround time
1 Day
Level of Service
- Technical Only
New York Approved: Yes
Specimen Requirements
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88342 x 1 or 88341 x 1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 22, 2025