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CD117 cKIT
- Immunohistochemistry (IHC)
CD117 (cKit) is a transmembrane receptor tyrosine kinase. It is expressed in many tissues and cells, such as tissue mast cells, skin basal cells, melanocytes, breast glandular epithelial cells, dermal sweat gland, esophageal glands, testicular and ovarian interstitial cells. Abnormal expression of cKit has been implicated in pathogenesis of myeloid leukemias. cKit expression has also been demonstrated in solid tumors including gastrointestinal stromal tumor (GIST), melanomas, breast carcinomas and small cell lung carcinoma. C-Kit pharmDXTM is indicated as an aid in the differential diagnosis of GIST. Accurate assessment of CD117 protein expression using cKIT testing is a critical factor in the diagnosis of GIST and is becoming increasingly important in clinical management, including the use of imatinib mesylate (Gleevec®) therapy.
Turnaround time
Tech-Only (stain only): 1 Day
Level of Service
- Technical Only
New York Approved: Yes
Specimen Requirements
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88342 x 1 or 88341 x 1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 22, 2025