Press Releases

Immunohistochemistry and alternative FISH testing in breast cancer with HER2 equivocal amplification

Published in Springer’s Breast Cancer Research and Treatment, March 2018
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Publications

Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues
Published in Annals of Diagnostic Pathology, February 2019
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A real-world, comparative study of FDA-approved diagnostic assays PD-L1 IHC 28-8 and 22C3 in lung cancer and other malignancies
Published in Journal of Clinical Pathology, October 2018
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Immunohistochemistry and alternative FISH testing in breast cancer with HER2 equivocal amplification
Published in Springer Breast Cancer Research and Treatment, March 2018
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Correlation of MET gene amplification and TP53 mutation with PD-L1 expression in non-small cell lung cancer
Published in Oncotarget, February 2018
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Use of CD42b immunohistochemical stain for the detection of Histoplasma
Published in Annals of Diagnostic Pathology, February 2018
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Prostatectomy-based validation of combined urine and plasma test for predicting high grade prostate cancer
Published in The Prostate, January 2018
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Autoimmune and medication-induced lymphadenopathies
Published in Seminars in Diagnostic Pathology, November 2017
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Lymph node stromal and vascular proliferations
Published in Seminars in Diagnostic Pathology, November 2017
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Lymphadenopathy associated with IgG4-related disease: Diagnosis & differential diagnosis
Published in Seminars in Diagnostic Pathology, November 2017
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A Multi-Center Prospective Study to Validate an Algorithm Using Urine and Plasma Biomarkers for Predicting Gleason ≥3+4 Prostate Cancer on Biopsy
Published in Journal of Cancer, August 2017
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Prevalence of somatic mutations in patients with aplastic anemia using peripheral blood cfDNA as compared with BM
Published in Leukemia, August 2017
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Significant Improvement in Detecting BRAF, KRAS, and EGFR Mutations Using Next-Generation Sequencing as Compared with FDA-Cleared Kits
Published in Springer Nature’s Molecular Diagnosis & Therapy Journal, June 2017
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Acquired RhD mosaicism identifies fibrotic transformation of thrombopoietin receptor-mutated essential thrombocythemia
Published in Transfusion Journal, June 2017
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Wild-type blocking PCR combined with direct sequencing as a highly sensitive method for detection of low-frequency somatic mutations
Published in Journal of Visualized Experiments, March 2017
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Using high-sensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors
Published in Oncotarget, February 2017
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Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemia
Published in Blood, January 2017
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Aggressive B-cell lymphomas: frequency, immunophenotype, and genetics in a reference laboratory population
Published in Annals of Diagnostic Pathology, August 2016
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Deep Sequencing of Cell-Free Peripheral Blood DNA as a Reliable Method for Confirming the Diagnosis of Myelodysplastic Syndrome
Published in Genetic Testing and Molecular Biomarkers, June 2016
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Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages
Published in Blood, June 2016
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Predicting prostate biopsy results using a panel of plasma and urine biomarkers combined in a scoring system
Published in Journal of Cancer, February 2016
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Chimerism analysis of cell-free DNA in patients treated with hematopoietic stem cell transplantation may predict early relapse in patients with hematologic malignancies
Published in Biotechnology Research International, January 2016
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Positive selection and high sensitivity test for MYD88 mutations using locked nucleic acid
Published in International Journal of Laboratory Hematology, January 2016
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Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma
Published in Annals of Diagnostic Pathology, June 2015
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Synonymous polymorphisms in HOXB13 as a predictive factor for prostate cancer
Published in Journal of Cancer, February 2015
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Correlations between cytogenetic and molecular monitoring among patients with newly diagnosed chronic myeloid leukemia in chronic phase: post hoc analyses of the rationale and insight for Gleevec high-dose therapy study
Published in Archives of Pathology & Laboratory Medicine, September 2014
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Diagnostic and prognostic scoring system for prostate cancer using urine and plasma biomarkers
Published in Genetic Testing & Molecular Biomarkers, March 2014, Vol. 18(3), pages 156-63.
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Abstracts and Posters

Using MultiOmyx™ to Analyze Correlations between Immunosuppressive Cells and Tumor-Infiltrating Lymphocytes in the Pancreatic Tumor Microenvironment
Presented at ESMO 2018
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Using a Multiplexed Immunofluorescence Assay to Detect Immunosuppressive Cells and their Mechanisms in the Pancreatic Tumor Microenvironment
Presented at ESMO 2018
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Characterization of Myeloid-Derived Suppressor Cells and Tumor Associated Macrophages Using MultiOmyx Hyperplexed Immuno-Assay in Hodgkin Lymphoma
Presented at the 2018 Annual Meeting of the American Society of Hematology
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Molecular Epidemiologic Associations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Within the United States
Presented at the 2018 Annual Meeting of the American Society of Hematology
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Validation of Clinical Prognostic Models and Integration of Genetic Biomarkers of Drug Resistance in CLL Patients Treated with Ibrutinib
Presented at the 2018 Annual Meeting of the American Society of Hematology
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Venetoclax in Combination with FLAG-IDA Chemotherapy (FLAG-V-I) for Fit, Relapsed/Refractory AML Patients: Interim Results of a Phase 1b/2 Dose Escalation and Expansion Study
Presented at the 2018 Annual Meeting of the American Society of Hematology
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Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome (MDS)
Presented at the 2018 Annual Meeting of the American Society of Hematology
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Clinicopathologic Characteristics and Novel Biomarkers of Aggressive B-Cell Lymphomas in the Nasopharynx
Presented at the 19th Annual European Association for Hematopathology
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Mismatch Repair Deficiency Testing for Immune Checkpoint Blockade Therapy: Immunohistochemistry vs Microsatellite Instability
Presented at the 2018 Annual Meeting of the American Society of Clinical Oncology
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Identifying New Biomarkers and Targeted Molecules for Immunotherapy Using Targeted RNA Next Generation Sequencing
Presented at the 2018 Annual Meeting of the American Society of Clinical Oncology
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Association between microsatellite instability and BRAF, TP53, PTEN, and KRAS mutations in colorectal cancer
Abstract published in conjunction with the 2018 Annual Meeting of the American Society of Clinical Oncology (ASCO). J Clin Oncol 36, 2018 (suppl; abstr e15604)
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Efficient Large Scale Cell Classification and Analysis for MultiOmyx™ Assays: A Deep Learning Approach
Presented at the 2018 Annual Meeting of the American Association for Cancer Research
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Immunohistochemistry and Alternative FISH Testing in Breast Cancer with HER2 Equivocal Amplification
Presented at the 2018 Annual Meeting of the American Association for Cancer Research
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Tumor-Infiltrating Myeloid Cells – Using MultiOmyx™ to Distinguish between TAMs, TANs, and MDSCs in the Pancreatic Tumor Microenvironment
Presented at the 2018 Annual Meeting of the American Association for Cancer Research
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MDS Diagnosis Using cfRNA Profiling By Targeted Enrichment Next Generation Sequencing
Presented at the 2017 Annual Meeting of the American Society of Hematology
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Liquid Biopsy As a Diagnostic Test for Myelodysplastic Syndrome and Other Acute and Chronic Myeloid Neoplasms
Presented at the 2017 Annual Meeting of the American Society of Hematology
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Clonal Hematopoiesis in Normal Individuals Is Not Random and Likely Reflects Early MDS
Presented at the 2017 Annual Meeting of the American Society of Hematology
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FLT3 Mutation in Acute Myeloid Leukemia: Primary or Secondary Mutation?
Presented at the 2017 Annual Meeting of the American Society of Hematology
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CD49d Expression in Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma: A Reference Laboratory Perspective
Presented at the 32nd Annual Clinical Cytometry Meeting
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An APL Case without a Detectable RARA Gene Rearrangement
Presented at the 2017 Annual Meeting of Association of Genetic Technologists (AGT)
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BRAF mutation and PD-L1 expression in melanoma: Comparison between multiple PD-L1 IHC clones and BRAF mutation evaluated by FDA-approved kits versus NGS
Abstract published in conjunction with the 2017 Annual Meeting of the American Society of Clinical Oncology (ASCO). J Clin Oncol 35, 2017 (suppl; abstr e21050)
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Expression of PD-L1 in colorectal cancer that lack mutations in RAS or TP53 genes
Abstract published in conjunction with the 2017 Annual Meeting of the American Society of Clinical Oncology (ASCO). J Clin Oncol 35, 2017 (suppl; abstr e14500)
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Combined Urine and Plasma Biomarkers are Highly Accurate for Predicting High Grade Prostate Cancer
Presented at the 2017 Annual Meeting of the American Urological Association (AUA)
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Correlation Between MET Gene Amplification and TP53 Mutation in Upregulating PD-L1 Expression in EGFR-Wild-Type Lung Cancer
Presented at the 2017 Annual Meeting of American Association for Cancer Research (AACR)
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Integrated Analysis of MicroRNA, mRNA, and Protein Expression Utilizing MultiOmyxTMand NanoStringTMfrom Formalin-Fixed Paraffin-Embedded Lung, Head and Neck, Breast, and Melanoma Tumors
Presented at the 2017 Annual Meeting of American Association for Cancer Research (AACR)
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Expression of platelet-associated marker CD42b on histoplasma
Presented at the 2017 Annual Meeting of the US and Canadian Academy of Pathology
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The life and death of the germinal center: an immunohistochemical analysis
Presented at the 2017 Annual Meeting of the US and Canadian Academy of Pathology
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Development and validation of automated flow cytometry system for the diagnosis and prediction of molecular abnormalities in myelodysplastic syndrome
Presented at the 2016 Annual Meeting of the American Society of Hematology
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Higher mutation rate in patients with aplastic anemia using peripheral blood cfDNA as compared with bone marrow cells
Presented at the 2016 Annual Meeting of the American Society of Hematology
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Interclonal and intraclonal heterogeneity in patients with IDH1/2 mutation
Presented at the 2016 Annual Meeting of the American Society of Hematology
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Using next generation sequencing of peripheral blood cfDNA as a clinical test in screening for hematologic neoplasms
Presented at the 2016 Annual Meeting of the American Society of Hematology
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PD-L1 expression correlates with TP53 gene mutation status in lung cancer but not in colorectal cancer
Presented at the 2016 Annual Meeting of the American Society of Clinical Oncology
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Immunohistochemical and genetic evaluation of double-hit lymphomas
Presented at the 2016 United States and Canadian Academy of Pathology Annual Meeting
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Correlation of MYC rearrangement with MYC immunohistochemistry in aggressive B-cell lymphomas
Presented at the 2016 United States and Canadian Academy of Pathology Annual Meeting
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Aggressive B-cell lymphoma in extreme age groups; Review of a series of 760 cases
Presented at the 2016 United States and Canadian Academy of Pathology Annual Meeting
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Aggressive B-cell lymphomas of the respiratory system: histologic, immunohistochemical and genetic evaluation of a large series
Presented at the 2016 United States and Canadian Academy of Pathology Annual Meeting
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MLL: The gene and its translocation partners. 2 cases with a t(11;17) involving MLL and mimicking the variant t(11;17) RARA translocation
Presented at the 2016 Annual Meeting of the Association of Genetic Technologists
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Gene mutations in cases suspected of MDS with loss of the Y chromosome as the sole abnormality
Presented at the 2016 Annual Meeting of the American College of Medical Genetics and Genomics
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High sensitivity testing shows multiclonal mutations in patients with CLL treated with BTK inhibitor and lack of mutations in ibrutinib-naïve patients
Presented at the 2015 Annual Meeting of the American Society of Hematology
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Interclonal and intraclonal heterogeneity in patients with early myelodysplastic syndrome (MDS)
Presented at the 2015 Annual Meeting of the American Society of Hematology
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The role of molecular profiling of bone marrow samples in confirming the diagnosis of myelodysplastic syndrome in patients presenting with cytopenia
Presented at the 2015 Annual Meeting of the American Society of Hematology
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Classification of acute myeloid & myelodysplastic syndrome based on molecular profiling
Presented at the 2015 Annual Meeting of the American Society of Hematology
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Gene mutations in MDS associating with peripheral blood count abnormalities
Presented at the 2015 Annual Meeting of the American Society of Human Genetics
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ALK positivity rate is highly dependent on patient age
Presented at the 2015 United States and Canadian Academy of Pathology Annual Meeting
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Genetic array analysis of follicular dendritic cell carcinoma
Presented at the 2015 United States and Canadian Academy of Pathology Annual Meeting
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Deep sequencing of peripheral blood plasma DNA as a reliable test for confirming the diagnosis of MDS
Presented at the 2014 Annual Meeting of the American Society of Hematology
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Determining tumor load and biallelic mutation in patients with CALR mutation using peripheral blood plasma
Presented at the 2014 Annual Meeting of the American Society of Hematology
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Molecular profiling in confirming the diagnosis of early myelodysplastic syndrome
Presented at the 2014 Annual Meeting of the American Society of Hematology
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Complete molecular risk stratification of de novo acute myeloid leukemia with intermediate cytogenetics using a nine-gene panel
Presented at the 2014 Annual Meeting of the American Society of Hematology
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Molecular profiling in determining diagnosis and prognosis of "early" myelodysplastic syndrome
Presented at the 2014 Annual Meeting of the American Society of Human Genetics
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Hyper-plexed biomarker imaging using the MultiOmyx™ platform enables novel systems biology insights for the diagnosis and treatment of disease
Presented at the 2014 Annual International Conference of Intelligent Systems for Molecular Biology
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Using a combination of plasma and urine biomarkers along with serum PSA in predicting prostate cancer and screening for high-risk cancer
Presented at the 2014 Annual Meeting of the American Society of Clinical Oncology
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Characterization of diverse immune cell types in single cancer tissue specimens using hyper-plexed in situ immunofluorescence staining technology
Presented at the 2014 Annual Meeting of the American Association for Cancer Research
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MultiOmyx™: A novel chemistry and visualization tools to aid resolution of discrepant Hodgkin Lymphoma cases. A single slide multiplex assay for the evaluation of classical Hodgkin Lymphoma
Presented at the 2013 Annual Meeting of the American Society of Hematology
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MultiOmyx™: A novel multiplex methodology for the evaluation of Hodgkin Lymphoma
Presented at the 2013 Annual Meeting of the Association for Molecular Pathology
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The use of FISH in detecting ROS1 gene rearrangements in non-small cell lung cancer
Presented at the 2013 Annual Meeting of the Association of Genetic Technologists
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A rare case of a complex variant Philadelphia chromosome translocation in CML
Presented at the 2012 Annual Meeting of the Association of Genetic Technologists
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Feasibility of Peripheral Blood Sampling and Correlation Between Early and Late Responses in Patients With Ph+ CML in Chronic Phase: Post-Hoc Analyses of Molecular Monitoring of Imatinib Response in the RIGHT Study
Presented at the European School of Hematology (ESH) International Conference on Chronic Myeloid Leukemia
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A Case for Performing Molecular Analysis on Challenging Melanocytic Lesions
Presented at the 2011 International Melanoma Congress
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Fluorescent In Situ Hybridization: Utility and Limitations for the Analysis of Melanocytic Lesions
Presented at the 2011 International Melanoma Congress
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Detection of Esophageal Adenocarcinoma (EAC) by a Four-Probe Fluorescence in situ Hybridization (FISH) Assay
Presented at the 2011 Annual Meeting of the American College of Gastroenterology
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DNA Abnormalities in Benign Barrett’s Esophagus (BE) are associated with Subsequent Progression to Esophageal Adenocarcinoma (EAC)
Presented at the 2011 Annual Meeting of the American College of Gastroenterology
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Fluorescence in-situ Hybridization (FISH) in Atypical Melanocytic Proliferations and Melanoma of Young Patients
Presented at the 2011 Annual Meeting of the American Society of Dermatopathology
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FISH as an effective diagnostic tool for the management of challenging melanocytic lesions
Published: August 11, 2011
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Development and Validation of a Fluorescence in-situ Hybridization (FISH) Based Assay as an Adjunct to Histopathology in the Diagnosis of Melanoma
Presented at the 2010 Annual Meeting of the Association of Genetic Technologists
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Plasma Cell Enrichment Manual versus Automated Methods
Presented at the 2010 Annual Meeting of the Association of Genetic Technologists
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Detection of PNH Cells in the bone marrow
Presented at the 2010 Annual Meeting of the Clinical Cytometry Society
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