Test by Disease - Lung

85 Tests in Listing


AFB

Special stain. Ziehl-Neelsen Acid-Fast Bacilli Stain is used to detect the presence of acid-fast mycobacteria in tissue sections. Acid-fast techniques...

IHC

Alcian Blue

Special stain. Alcian blue is intended to identify weakly sulfated mucins in tissue samples.

IHC

ALK (D5F3)

VENTANA FDA approved ALK (D5F3) CDx Assay is intended for the qualitative detection of the anaplastic lymphoma kinase (ALK) protein in formalin-fixed,...

IHC

ALK for NSCLC

Probes: ALK (2p23)
Disease(s): Non-small cell lung carcinoma (NSCLC)

FISH

ALK Mutation Analysis

Bi-directional Sanger sequencing of ALK is performed using PCR primers designed to target hotspot mutations in exons 23 and 25.

Molecular

BAP1

BAP1 IHC stain is a tool for detection of BAP1 mutations with subsequent inactivation. Loss of BAP1 by IHC is 100% specific for malignant mesothel...

IHC

BerEP4

Ber-EP4 recognizes two glycoproteins of 34 and 49 kDa present on the surface and the cytoplasm of all epithelial cells except the superficial layers ...

IHC

BG8

This antibody is specific for the Lewis Y (Type 2 Chain) carbohydrate antigen. Lewis Y has been evaluated as a clinical marker for the diagnosis and p...

IHC

Calretinin

Calretinin is the most specific and reproducible positive marker of epithelial mesothelioma. Calretinin is a calcium-binding protein similar to S100 p...

IHC

CAM 5.2 (CK LMW)

Anti-Cytokeratin (CAM 5.2) has a primary reactivity with human keratin proteins that correspond to Moll`s peptides #7 and #8, Mr 48 and 52 Kd. Cytoker...

IHC

CD163

CD163 antigen is restricted in its expression to the monocytic/macrophage lineage. It is present on all circulating monocytes and most tissue macropha...

IHC

CD31

CD31 is a 130kDa transmembrane glycoprotein that is shared by vascular lining cells, megakaryocytes and platelets. This marker is highly restricted to...

IHC

CEA (Poly)

Polyclonal carcinoembryonic antigen (CEA) antibody stains a larger percentage of cholangiocarcinomas compared to hepatocellular carcinomas. Approxima...

IHC

Chromogranin A

Chromogranin is present in several elements of the diffuse neuroendocrine system (DNES), including anterior pituitary, thyroid perifollicular C cells,...

IHC

CK AE1/AE3

Monoclonal antibodies AE1 and AE3 recognize the acidic and basic subfamilies of cytokeratin, respectively, thus the combination of these two antibodie...

IHC

CK HMW (CK903/34BE12)

CK903 (34betaE12) is a high molecular weight cytokeratin present in all squamous epithelium and their carcinomas. This antibody recognizes cytokeratin...

IHC

CK20

Cytokeratin 20 (CK20) positivity is seen in the majority of adenocarcinomas of the colon, mucinous ovarian carcinomas, transitional cell, and Merkel c...

IHC

CK5/6

D5/16 B4 clone of CK5/6 antibody reacts strongly with cytokeratins 5 and 6. Cytokeratin 5/6 have been found valuable for the distinction between low d...

IHC

CK7

Cytokeratin 7 (CK7) antibody reacts with proteins that are found in most ductal, glandular and transitional epithelium of the urinary tract and bile d...

IHC

cMET

The cMET tyrosine kinase receptor, normally expressed by epithelial cells, is overexpressed and amplified in a variety of human tumors, including non-...

IHC

CMV

In situ hybridization for detection of cytomegalovirus (CMV) RNA.

ISH

COX2

Cyclooxygenase-2 (COX-2) plays a role in tumorigenesis through stimulating epithelial cell proliferation, inhibiting apoptosis, stimulating angiogenes...

IHC

Desmin

Desmin is an intermediate filament protein of both smooth and striated muscles. Antibody to desmin reacts with striated (skeletal and cardiac) as well...

IHC

DNMT3A Mutation Analysis

Bi-directional sequencing of exon 26, a mutation hotspot region containing R882 and other mutations. In hematological disease, testing may be performe...

Molecular

EBER

This probe set labels all latent EBV-infected cells, including EBV-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infectio...

ISH

EGFR

Epidermal Growth Factor Receptor (EGFR) overexpression can occur in a variety of tumor types, including breast, prostate, ovarian, brain, lung and pre...

IHC

EGFR (E746-A750del specific)

Epidermal Growth Factor Receptor (EGFR) is a 170 kDa transmembrane receptor tyrosine kinase that belongs to the HER/ErbB protein family. Somatic mutat...

IHC

EGFR (L858R mutant specific)

Epidermal Growth Factor Receptor (EGFR) is a 170 kDa transmembrane receptor tyrosine kinase that belongs to the HER/ErbB protein family. Somatic mutat...

IHC

EGFR Mutation Analysis

Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations (including T790M) in...

Molecular

EGFR T790M Germline Mutation Analysis

Bidirectional sequence analysis of EGFR exon 20 in peripheral blood for detection of T790M germline mutation. Note: Patient and physician or genetic c...

Molecular

ERCC1

The Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1 (ERCC1) polypeptide is required for nucleotide excision repa...

IHC

Factor VIII RA

Factor VIII-related antigen is a component of Factor VIII complex. Factor VIII-related antigen is one of the available immunohistochemical markers of ...

IHC

HBME1

HBME1 is an anti-mesothelial monoclonal antibody that recognizes an unknown antigen on the microvilli of mesothelioma cells. It stains normal mesothel...

IHC

HSV I

This antibody reacts with Herpes Simplex Virus (HSV) type 1 specific antigens and with antigens common for HSV types 1 and 2. The antibody reacts with...

IHC

HSV II

This antibody reacts with Herpes Simplex Virus (HSV) type 2 specific antigens and with antigens common for HSV types 1 and 2. The antibody reacts with...

IHC

Ki67

Ki67 is a nuclear protein that is expressed in proliferating cells. Ki67 is preferentially expressed during late G1, S, M, and G2 phases of the cell ...

IHC

KRAS Exon 4 Mutation Analysis

Bi-directional sequencing of exon 4 of the KRAS gene corresponding to amino acids  R97 through Q150.  Codon 117 and 146 mutations are detected. For so...

Molecular

KRAS Mutation Analysis

Bi-directional sequencing of exons 2 and 3 of the KRAS gene. High-sensitivity sequencing is used for enhanced detection of mutations in codons 12, 13,...

Molecular

MET (c-MET) Mutation Analysis

Bi-directional Sanger sequencing of MET is performed using PCR primers designed to target hotspot mutations in exons 14, 16, 17 and 19.

Molecular

MET Exon 14 Deletion Analysis

MET Exon 14 Deletion Analysis is performed by fragment analysis using oligonucleotides designed to detect alternative splice junctions in exon 14 of t...

Molecular

MET FISH

Probes: MET (7q31) | Centromere 7
Disease(s): Multiple solid tumor cancers including lung (NSCLC), gastric, es...

FISH

MGMT Promoter Methylation Analysis

Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the MGMT gene promoter. Percentage of methylated DNA...

Molecular

MOC31

Monoclonal antibody MOC31 recognizes a membrane glycoprotein of 40kDa present on epithelial cells but not on mesothelial cells. MOC31 reacts with most...

IHC

MSA

Muscle Specific Actin (MSA) antibody recognizes the alpha and gamma isotypes of skeletal, cardiac, and smooth muscle cells. It is non-reactive with ot...

IHC

MUC1

Mucin 1 (MUC1) is a high molecular weight glycoprotein that is found on the apical surface of many glandular epithelia, including the gastrointestinal...

IHC

Mucicarmine

Special stain. Mucicarmine staining is used to identify epithelial mucins, namely acid mucopolysaccharides. Staining is useful to distinguishing mucin...

IHC

Napsin A

Napsin A has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors. ...

IHC

NeoARRAY™ SNP/Cytogenetic Profile

The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage a...

Cytogenetics

NeoARRAY™ SNP/Cytogenetic Profile

The NeoARRAY SNP/Cytogenetic Profile is available for hematological, solid tumor, and pregnancy loss indications. With the best genome-wide coverage a...

Molecular

NeoLAB™ EGFR T790M - Liquid Biopsy

The NeoLAB EGFR T790M - Liquid Biopsy test is a sequencing based assay that can detect the EGFR T790M mutation in plasma with high sensitivity (0.1...

Molecular

NeoLAB™ Solid Tumor Monitor - Liquid Biopsy

The NeoLAB™ Solid Tumor Monitor is a blood test that uses cell-free circulating tumor DNA (ctDNA) or RNA in combination with next-generation ...

Molecular

NeoTYPE™ Cancer Exome Profile

The NeoTYPE™ Cancer Exome Profile is performed by massive parallel sequencing of the coding regions in 4813 different cancer related genes. Test order...

Molecular

NeoTYPE™ Discovery Profile for Solid Tumors

This test is performed by the sequencing of select exons of the genes listed unless another method is noted. ABL1, ABL2, ACVR1B, AKT1, AKT2, AKT3, ...

Molecular

NeoTYPE™ Lung Tumor Profile

The NeoTYPE Lung Tumor Profile is performed by the sequencing of select exons of the genes listed unless another method is noted. AKT1, BRAF, EGFR,...

Molecular

NeoTYPE™ Other Solid Tumor Profile

This test is performed by the sequencing of select exons of the genes listed unless another method is noted. AKT1, BRAF, EGFR, FGFR1, FGFR2, FGFR3,...

Molecular

NeoTYPE™ Precision Profile for Solid Tumors

The NeoTYPE™ Precision Profile for Solid Tumors utilizes next-generation sequencing to detect mutations in the following 48 genes: ABL1, AKT1...

Molecular

NGS ALK, NTRK, RET, ROS1 Fusion Profile

The NGS ALK, NTRK, RET, ROS1 Fusion Profile is a targeted next-generation sequencing panel that detects significant translocations in the genes ALK (f...

Molecular

NGS ALK, RET, ROS1 Fusion Profile

The NGS ALK, RET, ROS1 Fusion Profile is a targeted next-generation sequencing panel that detects significant translocations in the genes ALK (fusions...

Molecular

NGS Thyroid Fusion Profile

The NGS Thyroid Fusion Profile is a targeted next-generation sequencing panel that detects significant translocations in the genes NTRK1 (fusions of e...

Molecular

NOTCH1 Mutation Analysis

Bi-directional sequencing of exons 26, 27, and 34 is performed for detection of sequence variant mutations. Testing can be performed on plasma when ad...

Molecular

NRAS Exon 4 Mutation Analysis

Bi-directional sequencing of NRAS exon 4 is performed using PCR primers designed to target hotspot mutations in codons 117 and 146, among other reg...

Molecular

NRAS Mutation Analysis

Bi-directional sequencing of NRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59, and 61.

Molecular

p21

p21 is a cyclin dependent protein kinase inhibitor and is a member of a family of proteins that functions to slow down cell division. p21 is found in ...

IHC

p27

p27 (KIP1) belongs to the family of cell cycle regulators that cause cell cycle arrest in G1 phase. p27 promotes apoptosis, plays a role in terminal d...

IHC

p40

p40 antibody recognizes δNp63—a p63 isoform. It is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to ...

IHC

p53

The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results ...

IHC

Pan Cancer NGS Expression/Fusion Panel

The Pan Cancer NGS Expression/Fusion Panel is a targeted RNA sequencing panel that utilizes next-generation sequencing (NGS) to measure gene expres...

Molecular

PDGFRa Mutation Analysis

Bi-directional sequencing of exons 12 and 18 of the PDGFRA (platelet-derived growth factor alpha) gene. These ...

Molecular

PD-L1 28-8 FDA (OPDIVO®)

PD-L1 IHC 28-8 pharmDx is a qualitative immunohistochemical assay using Monoclonal Rabbit Anti-PD-L1, clone 28-8 intended for use in the detection of ...

IHC

PD-L1, 22C3 FDA (KEYTRUDA®)

PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 intended for use in the detection of P...

IHC

pHistone H3 (PHH3)

Phosphohistone H3 (PHH3) is a marker of cells in the late G2-M phase of the cell cycle. It is not expressed in apoptotic cells which may be confused w...

IHC

PIK3CA Mutation Analysis

Bi-directional sequencing of PIK3CA exons 1, 9, and 20 which are the most commonly-mutated regions of the gene.

Molecular

Pneumocystis Carinii ( Jiroveci)

This antibody is specific to P. carinii (P. Jiroveci). It stains P. carinii distinctly. The staining pattern is visualized as homogeneou...

IHC

RET FISH

Probes: RET (10q11.2)
Disease(s): Lung cancer, thyroid cancer

FISH

ROS1

Probes: ROS1 (6q22.1)
Disease(s): Non-small cell lung carcinoma (NSCLC)

FISH

ROS1

ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas and are associated with a response to the multi-targeted tyrosine kin...

IHC

STAT3 Mutation Analysis

Bi-directional sequencing of STAT3 exons 13-21 encompassing the DNA binding and SH2 domains.

Molecular

Surfactant

Pulmonary surfactant apoproteins play essential roles in keeping alveoli from collapsing at the end of expiration. SP-A is located mainly in type II p...

IHC

Synaptophysin

Antibody to synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types. In combination with chromogranin A and NSE antib...

IHC

Thrombomodulin (TM)

Thrombomodulin (TM) is a plasma membrane-related glycoprotein that has anticoagulant activity. TM antigen is found in several cell types, including m...

IHC

TP53 Mutation Analysis

Bi-directional sequencing of TP53 exons 4-9.

Molecular

TTF1

Thyroid Transcription Factory (TTF1) is found only in thyroid and thyroid tumors regardless of histologic type, as well as in lung carcinomas, includ...

IHC

UGT1A1 Genotyping

Lengths of the TA repeat polymorphism in the promoter region of the UTG1A1 gene are determined by fragment analysis using capillary electrophoresis. T...

Molecular

Vimentin

Vimentin is the major intermediate filament in a variety of mesenchymal cells, including endothelial cells, all fibroblastic cells, macrophages, Serto...

IHC

Warthin Starry

Special stain. Warthin Starry stain is intended to identify Helicobacter pylori and spirochete microorganisms in tissue samples.

IHC

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