BCR/ABL1 t(9;22)

Philadelphia chromosome, Philadelphia translocation

Methodology

FISH

Test Description

Probes: ABL1 (9q34); ASS1 (9q34; BCR (22q11.2)
Disease(s): CML, ALL, MPN
Note: For suspected ALL, STAT processing is available by request. Note STAT along with MD contact name and phone number to receive STAT results.

Clinical Significance

Translocation 9;22 is seen in chronic myelogenous leukemia and acute lymphoblastic leukemia.

Specimen Requirements

  • Bone Marrow Aspirate: 1-2mL Sodium Heparin Tube. EDTA tube is acceptable
  • Peripheral Blood: 2-5mL Sodium Heparin Tube. EDTA tube is acceptable
  • Fresh, Unfixed Tissue: Tissue in RPMI
  • Fluids: Equal parts RPMI to specimen volume.
  • Paraffin or Cut Slides: N/A

Storage & Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*

88374x1 automated. Codes may differ if manual analysis is performed.

Level of Service

  • Tech Only   
  • Global   

Turnaround Time

3-5 days. STAT results, when requested, are reported 12-24 hours from receipt in the NeoGenomics laboratory.


*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.


 

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